4-chloro-5H,6H,7H-pyrrolo[2,3-d]pyriMidine - Names and Identifiers
Name | 4-chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine
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Synonyms | Tofacitinib-7 Azilsartan medoxomil impurity347 4-Chlor-7H-pyrrolo[2,3-d]pyrimidin 4-Chlor-1H-pyrrolo[2,3-d]pyrimidin 4-Chloro-1H-pyrrolo[2,3-d]pyrimidine 1H-pyrrolo[2,3-d]pyrimidine, 4-chloro- 4-chloro-5H,6H,7H-pyrrolo[2,3-d]pyriMidine 4-chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine 5H-Pyrrolo[2,3-d]pyriMidine,4-chloro-6,7-dihydro-
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CAS | 16372-08-0
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InChI | InChI=1/C6H6ClN3/c7-5-4-1-2-8-6(4)10-3-9-5/h3H,1-2H2,(H,8,9,10) |
4-chloro-5H,6H,7H-pyrrolo[2,3-d]pyriMidine - Physico-chemical Properties
Molecular Formula | C6H6ClN3
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Molar Mass | 155.58 |
Density | 1.63±0.1 g/cm3(Predicted) |
Melting Point | 158.5-160 °C |
Boling Point | 252.4±50.0 °C(Predicted) |
Solubility | DMSO (Slightly), Methanol (Slightly) |
Appearance | Solid |
Color | Pale Tan |
pKa | 11.69±0.20(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
Refractive Index | 1.592 |
4-chloro-5H,6H,7H-pyrrolo[2,3-d]pyriMidine - Introduction
4-choro-6, 7-dihydro-5h-cryrolo [2,3-d]pyrimidine is an organic compound with the chemical formula C7H6ClN3. It is also known as Cl6-DHPM or 4-choro-6, 7-dihydro-5h-chrrolo [2,3-d]pyrimidine.
This compound has the following properties:
1. Appearance: The appearance of the Cl6-DHPM is white to light yellow crystalline powder.
2. Melting Point: its melting point range between 215-220 ℃.
3. Solubility: Good solubility in common organic solvents such as chloroform, methanol and dichloromethane.
Some of the main uses of
Cl6-DHPM include:
1. Chemical reagent: It can be used as a reagent in organic synthesis reactions, such as raw materials, intermediates and nucleophiles.
2. Drug research: Because of its special structure, Cl6-DHPM and its derivatives have potential application value in the field of drug research. They may have anti-inflammatory, anti-tumor and anti-viral activities.
The preparation method of 4-chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine is usually obtained through organic synthesis reaction, and the common methods include:
1. Bromopyrimidine and 4-chloro -3-pyridinamine react to obtain the Cl6-DHPM precursor compound, and then the target product is obtained by reduction reaction.
2. Chlorinated organic compounds and pyrimidine compounds undergo condensation reactions to generate Cl6-DHPM.
Like any chemical substance, you need to pay attention to its safety when using Cl6-DHPM:
1. Irritating: It may irritate the skin, eyes and respiratory tract, so you should wear the corresponding protective equipment during operation.
2. Toxic: Cl6-DHPM at high concentrations may have toxic effects on the human body, avoid inhalation and contact, and ensure that it is used in a well-ventilated laboratory environment.
3. Storage and handling: Cl6-DHPM should be stored in a dry, cool place, away from fire and oxidant. The disposal of waste should comply with the relevant environmental regulations.
Although Cl6-DHPM has potential application value and chemical research significance, in view of its toxicity and irritation, it is necessary to understand its safe operation guidelines before use, and strictly follow the relevant regulations and laboratory safety standards.
Last Update:2024-04-09 21:21:28